Scan-Briefs
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Scantibodies Contract Monoclonal Antibody Production INTRODUCTION Over the past ten years, Scantibodies has developed an efficient, cost effective system of manufacturing monoclonal antibodies on a contract basis. The following is a description of the overall system and procedures used when Scantibodies performs custom monoclonal antibody (MAB) production. There are two types of custom monoclonal antibody production: in vivo (typically in mice), and in vitro (using bioreactors). For cost, speed, and scale-up reasons, the in vivo type has been the most popular method of choice. Custom in vivo monoclonal antibody production is accomplished using a wide variety of cell lines. At Scantibodies, BALB/c mice are maintained in a breeding colony with a population of 100,000 or more mice. Other strains of mice (Swiss Webster, CAF-1, ICR, etc.) are also available for antibody production. Custom in vitro monoclonal antibody production is performed in different types of bioreactors. IN THIS BRIEF... . Overview & Introduction
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